N-CYANOACETYLMORPHOLINE
- Name N-CYANOACETYLMORPHOLINE
- CAS 15029-32-0
- Purity 99%
Product Details
Quality Manufacturer Supply High Purity 99% N-CYANOACETYLMORPHOLINE 15029-32-0 with Reasonable Price
- Molecular Formula: C7H10 N2 O2
- Molecular Weight: 154.169
- Vapor Pressure: 2.93E-05mmHg at 25°C
- Melting Point: 87 °C
- Refractive Index: 1.4880 (estimate)
- Boiling Point: 230.8°Cat760mmHg
- PKA: 5.48±0.20(Predicted)
- Flash Point: 93.4°C
- PSA： 53.33000
- Density: 1.173g/cm3
- LogP: -0.30322
N-CYANOACETYLMORPHOLINE(Cas 15029-32-0) Usage
|
General Description |
N-Cyanoacetylmorpholine is a chemical compound used as a reagent in various chemical reactions. It has a molecular formula of C7H10N2O2 and is also known as 4-morpholineacetonitrile. This organonitrogen compound falls under the category of morpholines. It is majorly known for its application in the synthesis of pharmaceuticals as it acts as an efficient coupling reagent. It is used as a substitute for carbodiimides in peptide synthesis. Its crystalline structure allows for good stability, making it a useful tool in chemical research. Handling and usage of N-Cyanoacetylmorpholine should be done with care due to its hazardous nature. |
InChI:InChI=1/C7H10N2O2/c8-2-1-7(10)9-3-5-11-6-4-9/h1,3-6H2
15029-32-0 Relevant articles
Synthesis and Docking Study of Novel Pyranocoumarin Derivatives
Karteek, S. Durga,Reddy, A. Gopi,Tej, M. Bhuvan,Rao, M. V. Basaveswara
, p. 272 - 282 (2021/04/02)
Abstract: A new series of fused tricycli...
A CO2-Catalyzed Transamidation Reaction
Yang, Yang,Liu, Jian,Kamounah, Fadhil S.,Ciancaleoni, Gianluca,Lee, Ji-Woong
, p. 16867 - 16881 (2021/11/18)
Transamidation reactions are often media...
Synthesis and biological evaluation of flavone-8-acrylamide derivatives as potential multi-target-directed anti Alzheimer agents and investigation of binding mechanism with acetylcholinesterase
Shaik, Jeelan Basha,Yeggoni, Daniel Pushparaju,Kandrakonda, Yelamanda Rao,Penumala, Mohan,Zinka, Raveendra Babu,Kotapati, Kasi Viswanath,Darla, Mark Manidhar,Ampasala, Dinakara Rao,Subramanyam, Rajagopal,Amooru, Damu Gangaiah
, (2019/05/17)
In a search for novel multifunctional an...
New Flavone-Cyanoacetamide Hybrids with a Combination of Cholinergic, Antioxidant, Modulation of β-Amyloid Aggregation, and Neuroprotection Properties as Innovative Multifunctional Therapeutic Candidates for Alzheimer's Disease and Unraveling Their Mechanism of Action with Acetylcholinesterase
Basha, Shaik Jeelan,Mohan, Penumala,Yeggoni, Daniel Pushparaju,Babu, Zinka Raveendra,Kumar, Palaka Bhagath,Rao, Ampasala Dinakara,Subramanyam, Rajagopal,Damu, Amooru Gangaiah
, p. 2206 - 2223 (2018/05/23)
In line with the modern multi-target-dir...
15029-32-0 Process route
-
-
110-91-8,99108-56-2
morpholine
-
-
105-56-6
ethyl 2-cyanoacetate
-
-
15029-32-0
4-cyanoacetylmorpholine
| Conditions | Yield |
|---|---|
|
In
neat (no solvent);
at 20 ℃;
Inert atmosphere;
|
100%
|
|
With
1,8-diazabicyclo[5.4.0]undec-7-ene;
In
2-methyltetrahydrofuran;
at 40 ℃;
for 4h;
|
87%
|
|
at 130 ℃;
for 4h;
|
75%
|
|
at 100 - 110 ℃;
for 3h;
|
71%
|
|
With
1,8-diazabicyclo[5.4.0]undec-7-ene;
In
tetrahydrofuran;
at 40 ℃;
|
62%
|
|
In
ethanol;
at 20 ℃;
|
58%
|
|
With
sodium ethanolate;
In
ethanol;
at 20 ℃;
for 24h;
|
33%
|
|
|
|
|
With
n-butyllithium;
Yield given. Multistep reaction;
1.) THF, hexane, -70 deg C, 10 min, 2.) RT, 30 min;
|
|
|
at 90 ℃;
for 48h;
Heating / reflux;
|
|
|
In
hexane;
|
|
|
at 20 ℃;
Inert atmosphere;
neat liquid;
|
|
|
at 20 - 70 ℃;
|
|
|
at 20 ℃;
for 50h;
|
|
|
for 5h;
Reflux;
|
|
|
In
ethanol;
Reflux;
|
|
|
at 20 ℃;
|
|
|
In
ethanol;
at 20 ℃;
|
|
|
In
ethanol;
for 4h;
Reflux;
|
-
-
110-91-8,99108-56-2
morpholine
-
-
372-09-8
cyanoacetic acid
-
-
15029-32-0
4-cyanoacetylmorpholine
| Conditions | Yield |
|---|---|
|
With
dicyclohexyl-carbodiimide;
In
dichloromethane;
for 24h;
Reflux;
|
99%
|
|
With
dicyclohexyl-carbodiimide;
In
dichloromethane;
at 20 ℃;
Reflux;
|
73%
|
|
morpholine; cyanoacetic acid;
With
dmap; benzotriazol-1-ol;
In
DMF (N,N-dimethyl-formamide);
at 0 ℃;
With
1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
DMF (N,N-dimethyl-formamide);
at 20 ℃;
for 18h;
|
28%
|
15029-32-0 Upstream products
-
110-91-8
morpholine
-
105-56-6
ethyl 2-cyanoacetate
-
16130-58-8
cyanoacetic acid chloride
-
372-09-8
cyanoacetic acid
15029-32-0 Downstream products
-
22714-92-7
2-{4-[bis-(2-chloro-ethyl)-amino]-phenylimino}-3-morpholin-4-yl-3-oxo-propionimidic acid methyl ester
-
22714-84-7
4-({4-[bis-(2-hydroxy-ethyl)-amino]-phenylimino}-cyano-acetyl)-morpholine
-
22714-83-6
4-({4-[bis-(2-chloro-ethyl)-amino]-phenylimino}-cyano-acetyl)-morpholine
-
57037-01-1
4-(4-amino-2-thioxo-3-p -tolyl-2,3-dihydro-thiazole-5-carbonyl)-morpholine
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