4-(Trifluoromethoxy)benzonitrile
- Name 4-(Trifluoromethoxy)benzonitrile
- CAS 332-25-2
- Purity 99%
Product Details
Quality manufacturer supply 4-(Trifluoromethoxy)benzonitrile 332-25-2 in stock with high standard
- Molecular Formula: C8H4F3NO
- Molecular Weight: 187.121
- Appearance/Colour: clear light yellow liquid
- Vapor Pressure: 0.624mmHg at 25°C
- Refractive Index: n20/D 1.452(lit.)
- Boiling Point: 192.5 °C at 760 mmHg
- Flash Point: 82.8 °C
- PSA： 33.02000
- Density: 1.34 g/cm3
- LogP: 2.45688
4-(Trifluoromethoxy)benzonitrile(Cas 332-25-2) Usage
|
General Description |
4-(Trifluoromethoxy)benzonitrile serves as an intermediate in the synthesis of fluvoxamine. |
InChI:InChI=1/C8H4F3NS/c9-8(10,11)13-7-3-1-6(5-12)2-4-7/h1-4H
332-25-2 Relevant articles
Electrochemical Trifluoromethoxylation of (Hetero)aromatics with a Trifluoromethyl Source and Oxygen
Ouyang, Yao,Qing, Feng-Ling,Xu, Xiu-Hua
supporting information, (2021/12/06)
Trifluoromethoxylated aromatics (ArOCF3)...
Development and Molecular Understanding of a Pd-Catalyzed Cyanation of Aryl Boronic Acids Enabled by High-Throughput Experimentation and Data Analysis
De Jesus Silva, Jordan,Bartalucci, Niccolò,Jelier, Benson,Grosslight, Samantha,Gensch, Tobias,Schünemann, Claas,Müller, Bernd,Kamer, Paul C. J.,Copéret, Christophe,Sigman, Matthew S.,Togni, Antonio
, (2021/11/10)
A synthetic method for the palladium-cat...
Radical C?H Trifluoromethoxylation of (Hetero)arenes with Bis(trifluoromethyl)peroxide
Dix, Stefan,Golz, Paul,Schmid, Jonas R.,Riedel, Sebastian,Hopkinson, Matthew N.
supporting information, p. 11554 - 11558 (2021/07/09)
Trifluoromethoxylated (hetero)arenes are...
One pot synthesis of aryl nitriles from aromatic aldehydes in a water environment
Chen, Qingqing,Han, Hongwei,Lin, Hongyan,Ma, Xiaopeng,Qi, Jinliang,Wang, Xiaoming,Yang, Yonghua,Zhou, Ziling
, p. 24232 - 24237 (2021/07/29)
In this study, we found a green method t...
332-25-2 Process route
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![3-methyl-4-nitro-1-(trifluoromethoxy)-6-(trifluoromethyl)-1H-benzo[d][1,2,3]triazol-3-ium trifluoromethanesulfonate](/upload/2026/5/9400caa3d1754656bf7eb8e6eb686849_708a7a9d-fd71-49c7-a1bc-0d42c9bd65af.png)
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3-methyl-4-nitro-1-(trifluoromethoxy)-6-(trifluoromethyl)-1H-benzo[d][1,2,3]triazol-3-ium trifluoromethanesulfonate
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100-47-0
benzonitrile
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-
332-25-2
4-(trifluoromethoxy)benzonitrile
-
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52771-22-9
1-cyano-3-trifluoromethoxybenzene
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-
63968-85-4
2-(trifluoromethoxy)benzonitrile
| Conditions | Yield |
|---|---|
|
With
tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate;
In
acetonitrile;
at 20 ℃;
for 1h;
Overall yield = 54 percentSpectr.;
Inert atmosphere;
Flow reactor;
Irradiation;
|
-
-
4-cyano-1- (trifluoromethoxy)pyridin-1-ium bis((trifluoromethyl)sulfonyl)amide
-
-
100-47-0
benzonitrile
-
-
332-25-2
4-(trifluoromethoxy)benzonitrile
-
-
52771-22-9
1-cyano-3-trifluoromethoxybenzene
-
-
63968-85-4
2-(trifluoromethoxy)benzonitrile
| Conditions | Yield |
|---|---|
|
With
tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate;
In
acetonitrile;
at 20 ℃;
for 1h;
Overall yield = 49 %Spectr.;
Sealed tube;
Inert atmosphere;
Irradiation;
|
332-25-2 Upstream products
-
100114-88-3
4-cyanophenyl trichloromethyl ether
-
407-14-7
1-bromo-4-(trifluoromethoxy)benzene
-
1130-90-1
1-naphthyl cyanate
-
544-92-3
copper(I) cyanide
332-25-2 Downstream products
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456-71-3
4-trifluoromethoxybenzamide
-
79619-25-3
1-[4-(trifluoromethoxy)phenyl]pentan-1-one
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87996-55-2
(4-chlorophenyl)(4-(trifluoromethoxy)phenyl)methanone
-
330-12-1
4-trifluoromethoxybenzoic acid
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