1-beta-D-arabinofuranosyl-5-fluoro-(1H,3H)-pyrimidine-2,4-dione
- Name 1-beta-D-arabinofuranosyl-5-fluoro-(1H,3H)-pyrimidine-2,4-dione
- CAS 131-06-6
- Purity 99%
Product Details
High quality purity >99% 1-beta-D-arabinofuranosyl-5-fluoro-(1H,3H)-pyrimidine-2,4-dione 131-06-6 for sale We provide high quality 1-beta-D-arabinofuranosyl-5-fluoro-(1H,3H)-pyrimidine-2,4-dione (CAS 131-06-6), at a very affordable prices to our customers.
1.What is the 1-beta-D-arabinofuranosyl-5-fluoro-(1H,3H)-pyrimidine-2,4-dione ?
1-beta-D-arabinofuranosyl-5-fluoro-(1H,3H)-pyrimidine-2,4-dione, commonly known as fludarabine, is a synthetic purine nucleoside analog that possesses antineoplastic and immunosuppressive properties. It is a potent inhibitor of DNA and RNA synthesis, which leads to the disruption of cell division and the death of rapidly dividing cells, including cancer cells. Fludarabine is primarily used in the treatment of chronic lymphocytic leukemia (CLL), non-Hodgkin's lymphoma, and other hematologic malignancies. Due to its immunosuppressive effects, it can also cause side effects such as bone marrow suppression, immunosuppression, and an increased risk of infection. Patients receiving fludarabine treatment must be closely monitored for potential complications.
Used in Oncology:
1-beta-D-arabinofuranosyl-5-fluoro-(1H,3H)-pyrimidine-2,4-dione is used as an antineoplastic agent for the treatment of chronic lymphocytic leukemia (CLL) and non-Hodgkin's lymphoma. It is effective in inhibiting the growth and proliferation of cancer cells by disrupting DNA and RNA synthesis, leading to cell death.
Used in Hematologic Malignancies:
In the field of hematology, 1-beta-D-arabinofuranosyl-5-fluoro-(1H,3H)-pyrimidine-2,4-dione is used as a therapeutic agent for various hematologic malignancies. Its ability to target rapidly dividing cells makes it a valuable tool in the management of these conditions.
Used in Immunosuppression:
Due to its immunosuppressive properties, 1-beta-D-arabinofuranosyl-5-fluoro-(1H,3H)-pyrimidine-2,4-dione is used in situations where the immune system needs to be suppressed, such as in the treatment of autoimmune diseases or in organ transplantation to prevent rejection.
2.What is the CAS number for 1-beta-D-arabinofuranosyl-5-fluoro-(1H,3H)-pyrimidine-2,4-dione ?
The CAS number of 1-beta-D-arabinofuranosyl-5-fluoro-(1H,3H)-pyrimidine-2,4-dione is 131-06-6.
More information of 1-beta-D-arabinofuranosyl-5-fluoro-(1H,3H)-pyrimidine-2,4-dione 131-06-6 are:
|
CAS?Number |
131-06-6 |
|
Density |
1.77g/cm3 |
|
Melting Point |
187-188 °C |
|
Boiling Point |
°Cat760mmHg |
|
Flash Point |
°C |
|
Refractive Index |
1.641 |
|
HS CODE |
2933599590 |
|
PSA |
124.78000 |
|
LogP |
-2.71280 |
|
Pka |
7.63±0.10(Predicted) |
3.What is the molecular formula of 1-beta-D-arabinofuranosyl-5-fluoro-(1H,3H)-pyrimidine-2,4-dione ?
The chemical formula of?1-beta-D-arabinofuranosyl-5-fluoro-(1H,3H)-pyrimidine-2,4-dione is C9H11 F N2 O6 which containing 9 Carbon atoms,11 Hydrogen atoms,1 Fluorine atoms,2 Nitrogen atoms and 6 Oxygen atoms,and the molecular weight, and the molecular weight of 1-beta-D-arabinofuranosyl-5-fluoro-(1H,3H)-pyrimidine-2,4-dione is 262.195
4.What is 1-beta-D-arabinofuranosyl-5-fluoro-(1H,3H)-pyrimidine-2,4-dione(131-06-6)used for?
1-beta-D-arabinofuranosyl-5-fluoro-(1H,3H)-pyrimidine-2,4-dione, commonly known as fludarabine, is a synthetic purine nucleoside analog that possesses antineoplastic and immunosuppressive properties. It is a potent inhibitor of DNA and RNA synthesis, which leads to the disruption of cell division and the death of rapidly dividing cells, including cancer cells. Fludarabine is primarily used in the treatment of chronic lymphocytic leukemia (CLL), non-Hodgkin's lymphoma, and other hematologic malignancies. Due to its immunosuppressive effects, it can also cause side effects such as bone marrow suppression, immunosuppression, and an increased risk of infection. Patients receiving fludarabine treatment must be closely monitored for potential complications.
InChI:InChI=1/C9H11FN2O6/c10-3-1-12(9(17)11-7(3)16)8-6(15)5(14)4(2-13)18-8/h1,4-6,8,13-15H,2H2,(H,11,16,17)/t4-,5-,6+,8-/m1/s1
Relevant articles related to 1-beta-D-arabinofuranosyl-5-fluoro-(1H,3H)-pyrimidine-2,4-dione:
|
Article |
Source |
|
- |
Reist et al. , p. 2208 (1961) |
|
Synthesis and anti-viral activity of a series of D- and l-2′-deoxy-2′-fluororibonucleosides in the subgenomic HCV replicon system |
Shi, Junxing,Du, Jinfa,Ma, Tianwei,Pankiewicz, Krzysztof W.,Patterson, Steven E.,Tharnish, Phillip M.,McBrayer, Tamara R.,Stuyver, Lieven J.,Otto, Michael J.,Chu, Chung K.,Schinazi, Raymond F.,Watanabe, Kyoichi A. , p. 1641 - 1652 (2007/10/03) |
5.High quality purity >99% 1-beta-D-arabinofuranosyl-5-fluoro-(1H,3H)-pyrimidine-2,4-dione 131-06-6 for sale
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