Methyl 2-aminothiophene-3-carboxylate
- NameMethyl 2-aminothiophene-3-carboxylate
- CAS4651-81-4
- Purity99%
Product Details
Manufacturers supply cost-effective and customizable Methyl 2-aminothiophene-3-carboxylate 4651-81-4
- Molecular Formula:C6H7NO2S
- Molecular Weight:157.193
- Appearance/Colour:white to light yellow crystal powder
- Vapor Pressure:0.013mmHg at 25°C
- Melting Point:76-81 °C(lit.)
- Refractive Index:1.598
- Boiling Point:259.451 °C at 760 mmHg
- PKA:0.10±0.10(Predicted)
- Flash Point:110.712 °C
- PSA：80.56000
- Density:1.32 g/cm3
- LogP:1.69810
Methyl 2-aminothiophene-3-carboxylate(Cas 4651-81-4) Usage
InChI:InChI=1/C6H7NO2S/c1-9-6(8)4-2-3-10-5(4)7/h2-3H,7H2,1H3
4651-81-4 Relevant articles
Design, synthesis, molecular docking and cytotoxic activity of novel urea derivatives of 2-amino-3-carbomethoxythiophene
Amperayani, Karteek Rao,Parimi, Umadevi,Penumutchu, Srinivasa R,Thangudu, Suresh,Vankayala, Raviraj,Vikram, Venugopalarao
, (2020)
Abstract: An efficient feasible route fo...
Design, synthesis, docking, molecular dynamics and bioevaluation studies on novel N-methylpicolinamide and thienopyrimidine derivatives with inhibiting NF-κB and TAK1 activities: Cheminformatics tools RDKit applied in drug design
Tan, Ninghua,Wang, Linxiao,Wang, Zhe,Zhang, Qian,Zhu, Wufu
, (2021/07/09)
Using cheminformatics tools RDKit and li...
Synthesis of novel 2-(1-adamantanylcarboxamido)thiophene derivatives. Selective cannabinoid type 2 (CB2) receptor agonists as potential agents for the treatment of skin inflammatory disease
Mugnaini, Claudia,Rabbito, Alessandro,Brizzi, Antonella,Palombi, Nastasja,Petrosino, Stefania,Verde, Roberta,Di Marzo, Vincenzo,Ligresti, Alessia,Corelli, Federico
, p. 239 - 251 (2018/10/24)
A set of CB2R ligands, based on the thio...
Iridium complex containing thieno-[2,3-d] pyrimidine group and application in electroluminescence device
-
Paragraph 0044-0047, (2018/03/09)
The invention disclose an iridium comple...
4651-81-4 Process route
-
-
40018-26-6
1,4-dithiane-2,5-diol
-
-
105-34-0
methyl 2-cyanoacetate
-
-
4651-81-4
Methyl 2-aminothiophene-3-carboxylate
| Conditions | Yield |
|---|---|
|
With
triethylamine; N,N-dimethyl-formamide;
In
methanol;
at 50 ℃;
for 0.05h;
Sealed tube;
Microwave irradiation;
Inert atmosphere;
|
94% |
|
With
triethylamine;
In
methanol;
at 0 - 40 ℃;
|
86% |
|
With
triethylamine; N,N-dimethyl-formamide;
In
methanol;
at 50 ℃;
for 0.0333333h;
microwave irradiation;
|
82% |
|
With
triethylamine;
In
methanol;
at 0 - 60 ℃;
|
78% |
|
With
triethylamine;
In
methanol;
at -5 - 40 ℃;
for 4h;
|
77% |
|
With
triethylamine;
In
DMF (N,N-dimethyl-formamide);
at 0 - 20 ℃;
for 2h;
|
68% |
|
With
triethylamine;
In
N,N-dimethyl-formamide;
at 0 - 20 ℃;
for 3h;
|
64% |
|
With
triethylamine;
In
N,N-dimethyl-formamide;
at 25 - 45 ℃;
for 2.16667h;
|
58% |
|
With
triethylamine;
In
N,N-dimethyl-formamide;
at 25 ℃;
for 0.166667h;
|
58% |
|
With
triethylamine;
In
N,N-dimethyl-formamide;
at 45 ℃;
for 0.5h;
|
55% |
|
With
triethylamine;
In
methanol;
at 0 - 40 ℃;
for 2.5h;
|
44% |
|
With
triethylamine;
|
|
|
With
acetic acid; triethylamine;
In
N,N-dimethyl-formamide;
|
-
-
67-56-1
methanol
-
-
56387-08-7
2-aminothiophene-3-carboxylic acid
-
-
4651-81-4
Methyl 2-aminothiophene-3-carboxylate
| Conditions | Yield |
|---|---|
|
With
thionyl chloride;
at 0 ℃;
|
4651-81-4 Upstream products
-
40018-26-6
1,4-dithiane-2,5-diol
-
105-34-0
methyl 2-cyanoacetate
-
75-07-0
acetaldehyde
-
53982-98-2
2-cyano-but-2-enoic acid methyl ester
4651-81-4 Downstream products
-
14080-50-3
thieno[2,3-d]pyrimidin-4(3H)one
-
18740-38-0
1H-thieno[2,3-d]pyrimidine-2,4-dione
-
126637-07-8
methyl 2-isothiocyanato-thiophene-3-carboxylate
-
2125-85-1
3-hydroxypyrazolo<3,4-c>pyridazine
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