4-NITROQUINOLINE N-OXIDE
- Name 4-NITROQUINOLINE N-OXIDE
- CAS 56-57-5
- Purity 99%
Product Details
Reputable supplier selling 4-NITROQUINOLINE N-OXIDE 56-57-5 with stock
- Molecular Formula: C9H6 N2 O3
- Molecular Weight: 190.158
- Appearance/Colour: yellow-brown crystals or powder
- Melting Point: 154-156 °C(lit.)
- Refractive Index: 1.5570 (estimate)
- Boiling Point: 387.6 °C at 760 mmHg
- PKA: -1.83±0.10(Predicted)
- Flash Point: 188.2 °C
- PSA： 71.28000
- Density: 1.42 g/cm3
- LogP: 2.69970
4-NITROQUINOLINE N-OXIDE(Cas 56-57-5) Usage
|
Air & Water Reactions |
4-NITROQUINOLINE N-OXIDE is hygroscopic and light sensitive. Insoluble in water. |
|
Reactivity Profile |
4-NITROQUINOLINE N-OXIDE reacts with strong oxidizing agents. |
|
Health Hazard |
ACUTE/CHRONIC HAZARDS: 4-NITROQUINOLINE N-OXIDE may cause irritation. When heated to decomposition it may emit toxic fumes of carbon monoxide, carbon dioxide and nitrogen oxides. |
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Fire Hazard |
Flash point data for 4-NITROQUINOLINE N-OXIDE are not available; however, 4-NITROQUINOLINE N-OXIDE is probably combustible. |
|
Biochem/physiol Actions |
Skin and lung tumor initiator under experimental conditions. |
|
Safety Profile |
Suspected carcinogen with experimental carcinogenic, neoplas tigenic, and tumorigenic data. Poison by intraperitoneal and subcutaneous routes. An experimental teratogen. Other experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx. |
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Purification Methods |
The N-oxide recrystallises from aqueous acetone as yellow needles or platelets. [Ochiai J Org Chem 18 534 1953, Seki et al. J Phys Chem 91 126 1987, Beilstein 20 III/IV 3396.] |
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Definition |
ChEBI: A quinoline N-oxide carrying a nitro substituent at position 4. |
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General Description |
Yellowish-brown plates or needles or yellow solid. |
InChI:InChI=1/C9H7N2O3/c12-10-6-5-9(11(13)14)7-3-1-2-4-8(7)10/h1-6,8H/q+1
56-57-5 Relevant articles
Nitration of quinoline 1-oxide: Mechanism of regioselectivity
Yokoyama, Akihiro,Ohwada, Tomohiko,Saito, Shinichi,Shudo, Koichi
, p. 279 - 283 (1997)
The acidity dependence of orientation in...
Regioselective Cyanation of Six-Membered N-Heteroaromatic Compounds Under Metal-, Activator-, Base- and Solvent-Free Conditions
Sarmah, Bikash Kumar,Konwar, Monuranjan,Bhattacharyya, Dipanjan,Adhikari, Priyanka,Das, Animesh
supporting information, p. 5616 - 5625 (2019/11/22)
A regioselective cyanation of heteroarom...
Hypervalent Iodine(III)-Mediated Regioselective Cyanation of Quinoline N-Oxides with Trimethylsilyl Cyanide
Xu, Feng,Li, Yuqin,Huang, Xin,Fang, Xinjie,Li, Zhuofei,Jiang, Hongshuo,Qiao, Jingyi,Chu, Wenyi,Sun, Zhizhong
supporting information, p. 520 - 525 (2018/12/13)
A regioselective cyanation of quinoline ...
Conformational and structural analysis of bis(4-chloroquinoline-N-oxide)hydrogen tribromide
Romanov,Nizhnik, Ya. P.,Fofanov
, p. 365 - 369 (2015/06/08)
The X-ray diffraction and conformational...
Copper-catalyzed direct amination of quinoline N-oxides via C-H bond activation under mild conditions
Zhu, Chongwei,Yi, Meiling,Wei, Donghui,Chen, Xuan,Wu, Yangjie,Cui, Xiuling
supporting information, p. 1840 - 1843 (2014/05/06)
A highly efficient and concise one-pot s...
56-57-5 Process route
-
-
120309-60-6
C56 H98 O35 *C9 H6 N2 O3
-
-
56-57-5
4-nitroquinoline-N-oxide
-
-
51166-71-3
heptakis(2,6-di-O-methyl)cyclomaltoheptaose
| Conditions | Yield |
|---|---|
|
In
water;
at 25.5 ℃;
Equilibrium constant;
Thermodynamic data;
Mechanism;
concentration, temperature, complex formation, solvent effect, ΔH0=1.62 (+/- 0.13: kcal/mol); ΔS0=11.94 (+/- 0.46: cal/K*mol); in pH=7 buffer solution, I=0.5 with NaCl;
|
-
-
1613-37-2
Quinoline N-oxide
-
-
56-57-5
4-nitroquinoline-N-oxide
| Conditions | Yield |
|---|---|
|
With
trifluorormethanesulfonic acid; potassium nitrate; trifluoroacetic acid;
at 0 ℃;
for 25h;
|
92%
|
|
With
sulfuric acid; nitric acid;
In
water;
at 65 ℃;
for 2h;
|
88%
|
|
With
sulfuric acid; nitric acid;
at 65 ℃;
|
88%
|
|
With
sulfuric acid; nitric acid;
at 70 ℃;
for 3h;
|
23%
|
|
With
sulfuric acid; nitric acid;
|
|
|
With
sulfuric acid; potassium nitrate;
|
|
|
With
sulfuric acid; nitric acid;
|
|
|
With
sulfuric acid; nitric acid;
|
56-57-5 Upstream products
-
1613-37-2
Quinoline N-oxide
-
3741-15-9
4-nitroquinoline
-
120309-60-6
C56 H98 O35 *C9 H6 N2 O3
-
7664-93-9
sulfuric acid
56-57-5 Downstream products
-
20569-43-1
S -(1-oxy-[4]quinolyl)-L-cysteine
-
69619-12-1
4-phenoxyquinoline N-oxide
-
20146-26-3
4-phenylthioisoquinoline
-
115913-62-7
4-(phenylthio)quinoline 1-oxide
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